Alpha Medical Lab

Valproic Acid (Depakote)

Ordered Test Code:

VAP

Lab Test Component Requirement
Test Name Valproic Acid (Depakote)
Alpha’s Order Test Code VAP
Specimen Collection Tube Red Top (no gel)/1mL
Collection Tube Handling Plasma collected in: EDTA (lavender-top), sodium heparin (green-top), lithium heparin (green-top), sodium fluoride or potassium oxalate (gray-top), or 3.2% sodium citrate (light blue-top) tube
Minimum Volume 0.2mL
Transport Temperture Refrigerated
Stability Refrigerated: 7 days; Frozen: 30 days
Collection Instructions 1 mL serum collected in a red-top tube (no gel).

Clinical Significance

Valproic acid is used as an anticonvulsant to treat certain types of seizures, to prevent migraine headaches and to treat various psychiatric illnesses such as bipolar disorder and aggression. Drugs that compete for protein-binding sites with valproic acid can increase the concentration of valproic acid. Therapeutic drug monitoring is useful to optimize dose. Measurement of the free concentration is useful if toxicity is suspected.

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