Alpha Medical Lab

Aspartate Aminotransferase (AST)

Ordered Test Code:

AST

Lab Test Component	Requirement
Test Name	Aspartate Aminotransferase (AST)
Alpha’s Order Test Code	AST
Specimen Collection Tube	SST/ 1mL
Collection Tube Handling	Sodium heparin (green-top) tube, Lithium heparin (green-top) tube
Minimum Volume	0.5mL
Transport Temperture	Refrigerated
Stability	Service area must be determined.
Collection Instructions	1mL serum

Clinical Significance

AST is widely distributed throughout the tissues with significant amounts being in the heart and liver. Lesser amounts are found in skeletal muscles, kidneys, pancreas, spleen, lungs, and brain. Injury to these tissues results in the release of the AST enzyme to general circulation. In myocardial infarction, serum AST may begin to rise within 6-8 hours after onset, peak within two days and return to normal by the fourth or fifth day post infarction. An increase in serum AST is also found with hepatitis, liver necrosis, cirrhosis, and liver metastasis.