Alpha Medical Lab

Acetylcholine Receptor Binding Antibody

Ordered Test Code:

ACETYL

Lab Test Component	Requirement
Test Name	Acetylcholine Receptor Binding Antibody
Alpha’s Order Test Code	ACETYL
Specimen Collection Tube	SST/ 1mL
Collection Tube Handling
Minimum Volume	0.5mL
Transport Temperture	Refrigerated
Stability	Refrigerated: 14 days; Frozen: 30 days
Collection Instructions	1 mL serum

Clinical Significance

Myasthenia Gravis (MG) is an autoimmune neuromuscular disorder characterized by muscle weakness, most commonly due to autoantibody-mediated loss of functional acetylcholine receptors (AChR) in the neuromuscular junction. AChR binding autoantibodies are diagnostic of MG, and are found in 85-90% of MG patients. This assay aids in the differential diagnosis of conditions with MG-like muscle weakness and in monitoring therapeutic response. If binding antibodies are negative, assays for modulating and blocking antibodies should be considered.